Cervical Cancer Clinical Trials (as of April 2018)

ENGOT-cx10/GEICO-68-C/BEATcc

Leading group: GEICO

Clinical Trial Study: A randomized phase III trial of  platinum chemotherapy plus Paclitaxel with Bevacizumab and Atezolizumab versus platinum chemotherapy plus Paclitaxel and Bevacizumab in metastatic (stage IVB), persistent or recurrent carcinoma of the cervix (BEATcc).

Number of patients accrued: 0

Planned number of patients: 404

Participating groups: 

GINECO, ISGO, MaNGO, MITO, NSGO

Planned start in 3Q 2018

 

 

ENGOT-cx9/GEICO/REGN

Leading group: GEICO

Clinical Trial Study: An open-label, randomized, GOG/ENGOT phase 3 trial of anti-PD1 cemiplimab versus investigator's choice chemotherapy in >2 line recurrent cervical cancer

Number of patients accrued: 32

Planned number of patients: 436

Participating groups: 

BGOG, CEEGOG, MITO, PGOG

Planned start in 1Q 2018

 

 

ENGOT-cx8/BGOG-cx8/GCT1015-05

Leading group: BGOG

Clinical Trial Study: A phase 2 open-label trial of Tisotumab Vedotin (HuMax® - TF-ADC) alone or in combination in first line recurrent or stage IVB cervical cancer

Number of patients accrued: 0

Planned number of patients: 70

Participating groups: TBA

Planned start in 2Q 2018

 

  

ENGOT-cx7/NSGO/cc1-MaRuC

Leading group: NSGO

Clinical Trial Study: A randomized double-blind placebo-controlled phase II trial of Rucaparib maintenance therapy for patienst with locally advanced cancer - MaRuC

Number of patients accrued: 0

Planned number of patients: 162

Participating groups: 

BGOG, Cancer Trials Ireland, CEEGOG, EORCT, GEICO, ISGO, MITO, NCRI, NOGGO, PGOG

Planned start in 2Q 2018

 

 

ENGOT-cx6/BGOG-cx6/GCT1015-04

Leading group: BGOG

Clinical Trial Study: A single arm, multicenter, international trial of Tisotumab Vedotin (HuMax® - TF-ADC) in previously treated, recurrent or metastatic cervical cancer 

Number of patients accrued: 0

Planned number of patients: 100

Participating groups:

TBA

Planned start in 2Q 2018

 

 

ENGOT-cx5/A-AGO/ADVANCE

Leading group: A-AGO

Clinical Trial Study: ADVANCE (ADVAxis Immunotherapy with Nivolumab to treat recurrent or metastatic CErvical Cancer), A randomized phase II study to evaluate the safety and efficacy of ADXS-602 in combination with Nivolumab

Number of patients accrued: 0

Planned number of patients: 460

Participating groups: TBA

Planned start in 2018

 

 

ENGOT-cx4/GINECO/SENTICOL

Leading group: GINECO

Clinical Trial Study: International prospective validation trial of sentinel node biopsy in cervical cancer

Number of patients accrued: 0

Planned number of patients: 950

Participating groups: 

AGO, Cancer Trials Ireland, MaNGO, NCRI, NSGO

Planned start in 2018

 

 

ENGOT-cx3/CEEGOG/ABRAX

Leading group: CEEGOG

Clinical Trial Study: Abandoning of radical hysterectomy in cervical cancer - retrospective trial

Number of patients accrued: 56

Planned number of patients: 500

Participating groups: 

AGO, BGOG, MITO

Planned start in 2018

 

 

ENGOT-cx2/CEEGOG/SENTIX

Leading group: CEEGOG

Clinical Trial Study: SENTIX (SENTinel lymph node in cervIX cancer) - a prospective observational trial on sentinel lymph node biopsy in patients with early stage cervical cancer

Number of patients accrued: 284

Planned number of patients: 400

Participating groups:

BGOG, other TBA

 

 

ENGOT-cx1/BGOG-cx1

Leading group: BGOG

Clinical Trial Study: A randomized phase II trial of paclitaxel-carboplatin 3-weekly with or without Nintedanib (BIBFI 120) in advanced or recurrent cervical carcinoma

Number of patients accrued: 102

Planned number of patients: 120

Participating groups:

AGO, GEICO, MaNGO, MITO, NOGGO