Cervical Cancer Clinical Trials (as of August 12, 2020) ENGOT-cx14/CEEGOG/FERTISS Leading group: CEEGOG Clinical Trial Study: FERTISS - FERTIility Sparing Surgery in cervical cancer patients (outside trials) Planned number of patients: as many as possible Participating groups: AGO, BGOG, GINECO ENGOT-cx13/AGO/FERMATA Leading group: AGO Clinical Trial Study: FERMATA Trial: An international randomized double-blind clinical trial of BCD-100 plus platinum-based chemotherapy with and without Bevacizumab versus placebo plus platinum-based chemotherapy with and without Bevacizumab as first-line treatment of subjects with advanced cervical cancer Planned number of patients: 316 Participating groups: A-AGO, BGOG, CEEGOG, NSGO, PGOG, TRSGO Planned start in 3Q 2019 ENGOT-cx12/BGOG-cx12 Leading group: BGOG Clinical Trial Study: Phase 3, randomized controlled trial of Tisotumab Vedotin vs Investigator’s choice chemotherapy in 2nd or 3rd line recurrent cervical cancer Planned number of patients: 486 Participating groups: NSGO, AGO, MITO, GEICO, GINECO, A-AGO, CEEGOG, CTI, NCRI, DGOG, MaNGO, ISGO, HECOG Planned start in 2020 ENGOT-cx11/MITO/LACC Leading group: MITO Clinical Trial Study: A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer Planned number of patients: 786 Participating groups: MITO, MaNGO, BGOG, Cancer Trial Ireland, GINECO, HeCOG, CEEGOG, GEICO, ISGO, NCRI, G-AGO, NOGGO, NSGO, A-AGO Planned start in 1Q 2020 ENGOT-cx10/GEICO/BEATcc Leading group: GEICO Clinical Trial Study: A randomized phase III trial of platinum chemotherapy plus Paclitaxel with Bevacizumab and Atezolizumab versus platinum chemotherapy plus Paclitaxel and Bevacizumab in metastatic (stage IVB), persistent or recurrent carcinoma of the cervix (BEATcc). Planned number of patients: 404 Participating groups: AGO,GINECO, MaNGO, MITO, NSGO, JGOG, GOG-F ENGOT-cx9/GEICO/EMPOWER Cervical-1 Leading group: GEICO Clinical Trial Study: An open-label, randomized, GOG/ENGOT phase 3 trial of anti-PD1 cemiplimab versus investigator's choice chemotherapy in >2 line recurrent cervical cancer Planned number of patients: 534 Participating groups: BGOG, HEGOG, MITO, MaNGO, NCRI, PGOG Recruitment close in May 2020 ENGOT-cx8/BGOG-cx8/GCT1015-05 Leading group: BGOG Clinical Trial Study: A phase 2 open-label trial of Tisotumab Vedotin (HuMax® - TF-ADC) alone or in combination in first line recurrent or stage IVB cervical cancer Planned number of patients: 170 Participating groups: CEEGOG, CTI, DGOG, MITO, NCRI, NOGGO, NSGO, SGCTG, TRSGO Planned start in 2Q 2018 ENGOT-cx7/NSGO/cc1-MaRuC Leading group: NSGO Clinical Trial Study: A randomized double-blind placebo-controlled phase II trial of Rucaparib maintenance therapy for patienst with locally advanced cancer - MaRuC Planned number of patients: 162 Participating groups: BGOG, Cancer Trials Ireland, CEEGOG, EORCT, GEICO, ISGO, MITO, NCRI, NOGGO, PGOG Planned start in 2Q 2019 ENGOT-cx5/A-AGO/ADVANCE Leading group: A-AGO Clinical Trial Study: ADVANCE (ADVAxis Immunotherapy with Nivolumab to treat recurrent or metastatic CErvical Cancer), A randomized phase II study to evaluate the safety and efficacy of ADXS-602 in combination with Nivolumab Planned number of patients: 460 Participating groups: TBA Planned start in 2018 ENGOT-cx4/GINECO/SENTICOL Leading group: GINECO Clinical Trial Study: International prospective validation trial of sentinel node biopsy in cervical cancer Planned number of patients: 950 Participating groups: AGO, MaNGO, NSGO, DGOG, CEEGOG Planned start in 2018 ENGOT-cx2/CEEGOG/SENTIX Leading group: CEEGOG Clinical Trial Study: SENTIX (SENTinel lymph node in cervIX cancer) - a prospective observational trial on sentinel lymph node biopsy in patients with early stage cervical cancer Planned number of patients: 600 Participating groups: BGOG Publications: A prospective multicentre trial on sentinel lymph node biopsy in patients with early-stage cervical cancer (SENTIX) Cibula D, Dusek J, Jarkovsky J, Dundr P, Querleu D, van der Zee A, Kucukmetin A, Kocian R. Int J Gynecol Cancer. 2019 Jan;29(1):212-215 Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) Kristyna Nemejcova, Roman Kocian, Christhardt Kohler, Jiri Jarkovsky, Jaroslav Klat, Alberto Berjon, Radovan Pilka, Borek Sehnal, Blanca Gil-Ibanez, Ezequiel Lupo, Almerinda Petiz, Octavio Arencibia Sanchez, Peter Kascak, Fabio Martinelli, Alessandro Buda, Jiri Presl, Marc Barahona, Luc van Lonkhuijzen, Wiktor Szatkowski, Lubos Minar, Maja Pakiz, Pavel Havelka, Cristina Zorrero, Marcin Misiek, Leon Cornelius Snyman, Dariusz Wydra, Ignace Vergote, Alla Vinnytska, Mikulas Redecha, Martin Michal, Solveig Tingulstad, Barbara Kipp, Grzegorz Szewczyk, Robert Toth, Francisco Javier de Santiago Garcia, Pluvio Jesus Coronado Martin, Robert Poka, Karl Tamussino, Mathieu Luyckx, Maxime Fastrez, Juan Carlos Staringer, Anna Germanova, Andrea Plaikner, Sylva Bajsova, Pavel Dundr, Nina Mallmann-Gottschalk, David Cibula. Cancers journal (Cancers (Basel). 2020 Apr; 29;12(5): E1115 Sentinel lymph node mapping and intraoperative assessment in a prospective, international, multicentre, observational trial of patients with cervical cancer: The SENTIX trial David Cibula, Roman Kocian, Andrea Plaikner, Jiri Jarkovsky, Jaroslav Klat, Ignacio Zapardiel, Radovan Pilka, Aureli Torne, Borek Sehnal, Marcela Ostojich, Almerinda Petiz, Octavio Arencibia Sanchez, Jiri Presl, Alessandro Buda, Francesco Raspagliesi, Peter Kascak, Luc van Lonkhuijzen, Marc Barahona, Lubos Minar, Pawel Blecharz, Maja Pakiz, Dariusz Wydra, Leon Cornelius Snyman, Kamil Zalewski, Cristina Zorrero, Pavel Havelka, Mikulas Redecha, Alla Vinnytska, Ignace Vergote, Solveig Tingulstad, Martin Michal, Barbara Kipp, Jiri Slama, Simone Marnitz, Sylva Bajsova, Alicia Hernandez, Daniela Fischerova, Kristyna Nemejcova, Christhardt Kohler. 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