Ovarian Cancer Clinical Trials (as of August 3, 2021) ENGOT-ov67/AGO-OVAR 2.39 Leading group: AGO Clinical Trial Study: Uplifted expansion cohort in ovarian cancer patient of the open label Phase Ib/II, first-in-human, dose escalation and expansion study of XMT-1536 in patietns with solid tumors likely to express NaPi2 Planned number of patients: 180 Participating groups: BGOG, CEEGOG, GEICO, GINECO, MITO, NCRI, NOGGO, NSGO, PGOG ENGOT-ov66/GEICO Leading group: GEICO Clinical Trial Study: A Phase 3, Randomized, Double-Blind, Adaptive, Placebo/Paclitaxel-Controlled Study of AVB-S6-500 in Combination with Paclitaxel in Patients with Platinum-Resistant Recurrent Ovarian Cancer Planned number of patients: 150 Participating groups: TBA Planned start in September 2021 ENGOT-ov65/MaNGO Leading group: MaNGO Clinical Trial Study: TBA Planned number of patients: 616 Participating groups: GINECO, BGOG, NSGO, NOGGO, ISGO, PGOG, NCRI-UK, TRSGO, DGOG Planned start in 4Q 2021 ENGOT-ov64/NSGO-CTU/SOLERO Leading group: NSGO-CTU Clinical Trial Study: An Early Phase Randomized Trial of APX005M in BRCAwt Patients with Recurrent Ovarian Cancer Planned number of patients: 105 Participating groups: CEEGOG, BGOG, GEICO, Swiss-GO Planned start in 4Q 2021 ENGOT-ov63/GINECO/NIRVANA Leading group: GINECO Clinical Trial Study: NIRVANA (NIRaparib with or without beVacizumab in mAintenance after complete cytoreductioN in patients with ovArian cancer) Planned number of patients: 390 Participating groups: BGOG, MaNGO, DGOG,GEICO Planned start in 4Q 2021 ENGOT-ov62/NOGGO/N-PLUS Leading group: NOGGO Clinical Trial Study: NiraParib in optimaLly debUlked ovarian cancer patientS Planned number of patients: 536 Participating groups: TBA Planned start in 3Q 2021 ENGOT-ov61/GEICO/EPIK-O Leading group: GEICO Clinical Trial Study: EPIK-O: A Phase III, multi-center, randomized (1:1), openlabel, active-controlled study to assess the efficacy and safety of alpelisib (BYL719) in combination with olaparib as compared to single agent cytotoxic chemotherapy, in participants with no germline BRCA mutation detected, platinum-resistant or refractory, high-grade serous ovarian cancer Planned number of patients: 358 Participating groups: GINECO, NSGO, NCRI, CEEGOG, AGO, A-AGO, MITO, MaNGO and BGOG ENGOT-ov60/NCRI Leading group: NCRI Clinical Trial Study: A phase II trial of VS-6766 monotherapy and in combination with Defactinib in recurrent Low Grade Serous Ovarian Cancer Planned number of patients: 116 Participating groups: NCRI GOG partners, GEICO, BGOG, GINECO, MaNGO, Princess Margaret Consortium Canada Planned start in 3Q 2021 ENGOT-ov59/NOGGO/MAMOC Leading group: NOGGO Clinical Trial Study: Rucaparib MAintenance after Bevacizumab Maintenance following Carboplatin based first line chemotherapy in Ovarian Cancer patients Planned number of patients: 190 Participating groups: AGO ENGOT-ov58/GINECO/TEDOVA Leading group: GINECO Clinical trial Study: Neoepitope vaccine (TEDOPI) in combination with pembolizumab as maintenance treatment for ovarian cancer in platinum sensitive relapse Planned number of patients: 160 Participating groups: AGO, BGOG Planned start in 3Q 2021 ENGOT-ov57/AGO Leading group: AGO Clinical Trial Study: Niraparib vs Niraparib in combination with Bevacizumab in patients with carboplatinum-taxane based chemother-apy in advanced ovarian cancer Planned number of patients: 970 Participating groups: TBA Planned start in Q3 2021 ENGOT-ov56/NSGO-CTU/DOVACC Leading group: NSGO-CTU Clinical Trial Study: A three-arm randomized study of olaparib, durvalumab and UV1 as maintenance therapy in BRCAwt patients in with relapsed ovarian cancer where platatinum combination therapy is an option Planned number of patients: 184 Participating groups: BGOG, NOGGO, HeCOG, DGOG, A-AGO Planned start in Q3 2021 ENGOT-ov55/BGOG/MIRASOL Leading group: BGOG Clinical trial Study: MIRASOL: A phase 3 registration trial for Mirvetuximab-Soravtansine using PS2+ scoring in FRα high platinum resistant ovarian cancer patients Planned number of patients: 430 Participating groups: GEICO, DGOG, CEEGOG, ISGO, PGOG, MANGO, NCRI, AGO, GINECO ENGOT-ov54/Swiss-GO/MATAO Leading group: Swiss-GO Clinical Trial Study: MAintenance Therapy with Aromatase inhibitor in epithelial Ovarian cancer: a Randomized Double-blinded Placebo-controlled Phase III Trial Planned number of patients: 540 Participating groups: AGO, A-AGO Planned start in 4Q 2020 ENGOT-ov53/CEEGOG/Vitalia Leading group: CEEGOG Clinical Trial Study: A phase III, multicenter, randomized, double-blind, placebo-controlled add-on trial of DCVAC/OvCa added to second-line chemotherapy with or without bevacizumab in the induction period, followed by DCVAC/OvCa with either bevacizumab, PARP inhibitor or best supportive care in maintenance period in patients with first relapse of platinum-sensitive ovarian, fallopian tube, and primary peritoneal carcinoma Planned number of patients: 754 Participating groups: AGO-A, BGOG, DGOG, GEICO, NOGGO (including AGO sites), NSGO, PGOG, ManGo, MITO, SGCTG (including NCRI/MRC sites) Planned start in 3Q 2021 ENGOT-ov52/DGOG/OVHIPEC-2 Leading group: DGOG Clinical Trial Study: OVHIPEC-2 Randomized phase 3 trial comparing primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for stage III epithelial ovarian cancer Planned number of patients: 538 Participating groups: Cancer trials Ireland, ANZGOG, NSGO-CTU, MITO, GINECO, NCRI, USA (as guest member of the DGOG) ENGOT-ov51/MITO/NItCHE Leading group: MITO Clinical Trial Study: Randomized phase III trial on Niraparib-TSR 042 vs TSR 042 vs physician's choice chemotherapy in recurrent ovarian, fallopian tube or primary peritoneal cancer patients not candidate for further platinum treatment Planned number of patients: 427 Participating groups: MaNGO, GINECO, HeCOG, CEEGOG, NOGGO Planned start in 3Q 2020 ENGOT-ov50/BGOG/INNOVATE-3 Leading group: BGOG Clinical Trial Study: INNOVATE-3: Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields, 200kHz) concomitant with weekly paclitaxel for the treatment of platinum-resistant ovarian cancer (PROC) Planned number of patients: 540 Participating groups: GEICO, SAKK, MITO, MANGO, PGOG, NOGGO, CEEGOG, DGOG, ISGO, AGO ENGOT-ov49/MaNGO/NEWTON Leading group: MaNGO Clinical Trial Study: A multicenter, open-label phase II trial of customized dosing (Rapid Adjustment of Dose to reduce Adverse Reactions “RADAR” dosing) of niraparib as maintenance therapy in platinum sensitive ovarian, fallopian tube or primary peritoneal recurrent cancer patients. Planned number of patients: 105 Participating groups: NOGGO ENGOT-ov47-TR /NOGGO-AGO TR2/HELPER Leading group: NOGGO Clinical Trial Study: Prospective study of HE4 serum level in patients with first platinum sensitive relapsed ovarian cancer Planned number of patients: 500 Participating groups: A-AGO, AGO, BGOG, GEICO, MaNGO, MITO, NCRI ENGOT-ov46/AGO/DUO-O Leading group: AGO Clinical Trial Study: A phase III randomised, double-blind, placebo-controlled, multicentre study of Durvalumab in combination with chemotherapy and Bevacizumab, followed by maintenance Durvalumab, Bevacizumab and Olaparib in newly diagnosed advanced ovarian cancer patients (DUO-O) Planned number of patients: 1259 Participating groups: A-AGO, BGOG, GEICO, GINECO, MaNGO, MITO, NSGO, PGOG, TRSGO ENGOT-ov45/NCRI/ATHENA Leading group: NCRI Clinical Trial Study: ATHENA - A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment following Response to Front-Line Platinum-Based Chemotherapy Planned number of patients: 1000 Participating groups: AGO, BGOG, CEEGOG, CTI, GEICO, HeCOG, ISGO, MITO, NSGO, PGOG, TRSGO, (GOG Foundation Partners and other global groups) ENGOT-ov41/GEICO/ANITA Leading group: GEICO Clinical Trial Study: ANITA (Atezolizumab and NIraparib Treatment Association in recurrent ovarian cancer): A randomized phase III trial of platinum-based chemotherapy followed by niraparib maintenance with or without atezolizumab in patients with recurrent ovarian, tubal or peritoneal cancer and platinum treatment-free interval (TFIp) >6 Months Planned number of patients: 414 Participating groups: AGO, BGOG, GINECO, ISGO, MaNGO ENGOT-ov40/NOGGO/Expression VI Leading group: NOGGO Clinical Trial Study: Holistic Analysis of longterm survivors with ovarian cancer Planned number of patients: 600 Participating groups: A-AGO, BGOG, CEEGOG, GEICO, TRSGO, Swiss-GO, (Romania, PASGO) ENGOT-ov35/NCRI/ICON 9 Leading group: NCRI Clinical Trial Study: An international phase III randomised study to evaluate the efficacy of maintenance therapy with olaparib and cediranib or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer following a response to platinum-based chemotherapy Planned number of patients: 330 Participating groups: SGCTG (ANZGOG, NCIC) ENGOT-ov34/AGO Ovar 2.29 Leading group: AGO Clinical Trial Study: Atezolizumab in combination with Bevacizumab +/- Chemotherapy versus Chemo-BEV standard in recurrent ovarian cancer – a randomised trial Planned number of patients: 664 Participating groups: A-AGO, BGOG, GEICO, GINECO, NSGO, SAKK ENGOT-ov33/AGO Ovar OP.7/TRUST Leading group: AGO Clinical Trial Study: TRUST-Trial on Radical Upfront Surgical Therapy Planned number of patients: 772 Participating groups: GINECO, MaNGO, NSGO, NOGGO ENGOT-ov13/NCRI/ICON8 B Leading group: NCRI Clinical Trial Study: An international phase III randomised trial of dose fractionated chemotherapy compared to standard three weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer Planned number of patients: 590 Participating groups: Cancer Trials Ireland, CTU EOC (Swiss) Upcoming ENGOT Meeting ENGOT General Assembly October 6-7, 2022 Berlin, Germany Don't miss out on the latest updates and save the date! 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