Ovarian Cancer Clinical Trials (as of June 2019)

ENGOT-ov54/Swiss-GO/MATAO

Leading group: Swiss-GO

Clinical Trial Study: MATAO -  Maintenance Therapy with Aromatase inhibitor in epithelial Ovarian cancer: a Randomized Double-blinded Placebo-controlled Phase III Trial

Number of patients accrued: 0

Planned number of patients: 540

Participating groups:

AGO, A-AGO

Planned start in 4Q 2019 

 

ENGOT-ov53/CEEGOG/SOV09

Leading group: CEEGOG

Clinical Trial Study: A phase III, multicenter, randomized, double-blind, placebo-controlled add-on trial of DCVAC/OvCa added to second-line chemotherapy with or without bevacizumab in the induction period, followed by DCVAC/OvCa with either bevacizumab, PARP inhibitor or best supportive care in maintenance period in patients with first relapse of platinum-sensitive ovarian, fallopian tube, and primary peritoneal carcinoma

Number of patients accrued: 0

Planned number of patients: 678

Participating groups:

TBA

Planned start in 3Q 2019 

 

ENGOT-ov52/DGOG/OVHIPEC-2

Leading group: DGOG

Clinical Trial Study: OVHIPEC-2 Randomized phase 3 trial comparing primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for stage III epithelial ovarian cancer

Number of patients accrued: 0

Planned number of patients: 538

Participating groups:

NSGO, CTI, NCRI (ANZGOG)

Planned start in 4Q 2019 

 

ENGOT-ov51/MITO

Leading group: MITO

Clinical Trial Study: Randomized phase III trial on Niraparib-TSR 042 vs TSR 042 vs physician's choice chemotherapy in recurrent ovarian, fallopian tube or primary peritoneal cancer patients not candidate for further platinum treatment

Number of patients accrued: 0

Planned number of patients: 427

Participating groups:

TBA

Planned start in 1Q 2019 

 

ENGOT-ov50/BGOG/INNOVATE-3

Leading group: BGOG

Clinical Trial Study: INNOVATE-3: Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields, 200kHz) concomitant with weekly paclitaxel for the treatment of platinum-resistant ovarian cancer (PROC)

Number of patients accrued: 0

Planned number of patients: 540

Participating groups:

TBA

Planned start in 4Q 2018 

 

ENGOT-ov49/MaNGO/RADAR

Leading group: MaNGO

Clinical Trial Study: A multicenter, open-label phase II trial of customized dosing (Rapid Adjustment of Dose to reduce Adverse Reactions “RADAR” dosing) of niraparib as maintenance therapy in platinum sensitive ovarian, fallopian tube or primary peritoneal recurrent cancer patients.

Number of patients accrued: 0

Planned number of patients: 105

Participating groups:

AGO, NCRI

Planned start in 4Q 2018 

 

ENGOT-ov48/BGOG/EUDARIO

Leading group: BGOG

Clinical Trial Study: European trial on enhanced DNA repair Inhibion in ovarian cancer (EUDARIO).

Number of patients accrued: 6

Planned number of patients: 120

Participating groups:

A-AGO, GINECO, MITO, NOGGO

Planned start in June 2018

 

 

ENGOT-ov47-TR /NOGGO-AGO TR2 

Leading group: NOGGO

Clinical Trial Study: Prospective study of HE4 serum level in patients with first platinum sensitive relapsed ovarian cancer.

Number of patients accrued: 0

Planned number of patients: 500

Participating groups:

A-AGO, AGO, BGOG, GEICO, MaNGO, MITO, NCRI

Planned start in May 2018

 

 

ENGOT-ov46/AGO/DUO-O

Leading group: AGO

Clinical Trial Study: A phase III randomised, double-blind, placebo-controlled, multicentre study of Durvalumab in combination with chemotherapy and Bevacizumab, followed by maintenance Durvalumab, Bevacizumab and Olaparib in newly diagnosed advanced ovarian cancer patients (DUO-O)

Number of patients accrued: 144

Planned number of patients: 1056

Participating groups:

A-AGO, BGOG, GEICO, MaNGO, MITO, NSGO, PGOG, TRSGO

 

 

ENGOT-ov45/NCRI/ATHENA

Leading group: NCRI

Clinical Trial Study: ATHENA: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment following Response to Front-Line Platinum-Based Chemotherapy

Number of patients accrued: 86

Planned number of patients: 1000

Participating groups:

AGO-De, BGOG, CEEGOG, CTI, GEICO, HeCOG, ISGO, MITO, NSGO, PGOG, TRSGO

 

 

ENGOT-ov44/GINECO/FIRST trial

Leading group: GINECO

Clinical Trial Study: A randomized phase III comparing platinum and TSR-042 (PD-L1 inhibitor) followed by Niraparib and TSR-042 maintenance therapy versus  adaptive standard platinum-based treatment in patients with stage III or IV cancer of the ovary, fallopian tube or peritoneum

Number of patients accrued: 270

Planned number of patients: 700

Participating groups:

AGO, BGOG, CEEGOG, DGOG, GEICO, HeCOG, ISGO, MITO, NCRI, NSGO

 

 

ENGOT-ov43/BGOG

Leading group: BGOG

Clinical Trial Study: Randomized phase III first line study in ovarian cancer comparing paclitaxel carboplatinum, with paclitaxel/carboplatin and pembrolizumab and olaparib

Number of patients accrued: 17

Planned number of patients: 1500

Participating groups:

TBA

Planned start in 2Q 2018

 

 

ENGOT-ov42/NSGO/AVANOVA-Immune1

Leading group: NSGO

Clinical Trial Study: A randomized phase II trial to explore efficacy of Immune checkpoint inhibitor TSR042 in relapsed ovarian cancer

Number of patients accrued: 0

Planned number of patients: 368

Participating groups:

BGOG, CEEGOG, DGOG, GEICO, GINECO, ISGO, MaNGO, NCRI, NOGGO, PGOG, SGCTG, TRSGO

Planned start in 3Q 2018

 

 

ENGOT-ov41/GEICO/ANITA

Leading group: GEICO

Clinical Trial Study: ANITA (Atezolizumab and NIraparib Treatment Association in recurrent ovarian cancer): A randomized phase III trial of platinum-based chemotherapy followed by niraparib maintenance with or without atezolizumab in patients

Number of patients accrued: 42

Planned number of patients: 414

Participating groups:

TBA

 

 

ENGOT-ov40/NOGGO S13/Expression VI

Leading group: NOGGO

Clinical Trial Study: Caroline meets HANNA – Holistic analysis of longterm survivors with ovarian cancer

Number of patients accrued: 433

Planned number of patients: 600

Participating groups:

A-AGO, BGOG, CEEGOG, GEICO, MITO, TRSGO, (Romania, PASGO)

 

 

ENGOT-ov39/MITO/IMaGYN 050

Leading group: MITO

Clinical Trial Study: A phase III, multicenter, randomized, study of atezolizumab versus placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with paclitaxel, carboplatin, and bevacizumab to patients with newly-diagnosed Stage III or Stage IV ovarian, fallopian tube, or primary peritoneal cancer

Number of patients accrued: 1278

Planned number of patients: 1300

Participating groups:

A-AGO, AGO, BGOG, MaNGO, NSGO, CEEGOG, GEICO, GINECO, HeCOG, PGOG, TRSGO, ISGO

 

 

ENGOT-ov38/GINECO/OReO

Leading group: GINECO

Clinical Trial Study: Double blind phase IIIb study: Olaparib Retreatment in late recurrent Ovarian cancer

Number of patients accrued: 120

Planned number of patients: 228

Participating groups:

AGO, BGOG, GEICO, ISGO, MITO, NSGO, SGCTG, MaNGO, NCRI, PGOG

 

 

ENGOT-ov36/SGCTG – NSGO

Leading group: SGCTG

Clinical Trial Study: A phase II trial of a triple angiokinase inhibitor (BIBF1120) in the treatment of patients with recurrent clear cell ovarian cancer

Number of patients accrued: 93

Planned number of patients: 120

Participating groups:

EORTC, GINECO, NCRI, NSGO

 

 

ENGOT-ov35/NCRI/ICON 9

Leading group: NCRI

Clinical Trial Study: An international phase III randomised study to evaluate the efficacy of maintenance therapy with olaparib and cediranib or olaparib alone in patients with relapsed platinum-sensitive ovarian cancer following a response to platinum-based chemotherapy

Number of patients accrued: 11

Planned number of patients: 618

Participating groups:

MITO, CTI (ANZGOG, NCIC)

  

 

ENGOT-ov34/AGO Ovar 2.29

Leading group: AGO

Clinical Trial Study: Atezolizumab in combination with Bevacizumab +/- Chemotherapy versus Chemo-BEV standard in recurrent ovarian cancer – a randomised trial

Number of patients accrued: 37

Planned number of patients: 664

Participating groups: 

A-AGO, BGOG, GEICO, GINECO, NSGO, SAKK

 

 

ENGOT-ov33/AGO Ovar OP.7/TRUST

Leading group: AGO

Clinical Trial Study:

TRUST: Trial on Radical Upfront Surgical Therapy

Number of patients accrued: 691

Planned number of patients: 772

Participating groups:

GINECO, MaNGO, MITO, NOGGO

  

  

ENGOT-ov30/NSGO/UMB1

Leading group: NSGO

Clinical Trial Study: Umbrella Trial in Recurrent Ovarian Cancer

Number of patients accrued: 23

Planned number of patients: 25

Participating groups:

BGOG, EORTC, NOGGO, SGCTG, (ANZGOG, COGI, GOTIC, PMHC)

 

 

ENGOT-ov29/GINECO/ATALANTE

Leading group: GINECO

Clinical Trial Study: Randomized trial comparing atezolizumab versus placebo in patients with 1st or 2nd platinum-sensitive relapse of OC treated with carboplatin combination + bevacizumab

Number of patients accrued: 570

Planned number of patients: 600

Participating groups:

A-AGO, AGO, BGOG, CEECOG, GEICO, ISGO

 

 

ENGOT-ov 13/NCRI/ICON8

Leading group: NCRI

Clinical Trial Study: An international phase III randomised trial of dose fractionated chemotherapy compared to standard three weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer

Final number of patients: 1566

Participating groups:

Cancer Trials Ireland, (ANZGOG, GICOM, KGOG)

 

 

ENGOT-ov 13/NCRI/ICON8B

Leading group: NCRI

Clinical Trial Study: A phase III randomised trial investigating the combination of dose-fractionated chemotherapy and bevacizumab compared to standard three weekly chemotherapy and bevacizumab for the first-line treatment of women with newly diagnosed high-risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer

Number of patients accrued: 489

Planned number of patients: 660

Participating groups:

Cancer Trials Ireland, (CTU EOC)